Organooxygen compounds
Medchemexpress LLC Befiradol hydrochloride | 2436760-81-3 | MFCD31731608 | 99.9% | 430.32 g/mol | C20H23Cl2F2N3O | 10 MG
Befiradol hydrochloride is a selective 5-HT1A receptor agonist provided for research use. It modulates serotonergic and dopaminergic activity in cortical regions and is used in preclinical pharmacology studies to investigate 5-HT1A-mediated mechanisms and models of neurological disorders. The material is supplied with supporting documentation for analytical and safety purposes.
- Selective 5-HT1A receptor agonist for receptor pharmacology studies.
- Demonstrated activity on dorsal raphe and medial prefrontal cortex neurotransmission.
- High chemical purity suitable for analytical and in vivo research.
- Supplied with certificate of analysis and safety data sheet.
- Available in multiple pack sizes for small-scale and bulk use.
- Not for human or clinical use; for research use only.
Medchemexpress LLC Alosetron Hydrochloride | 122852-69-1 | 99.6% | C17H19ClN4O | 10 MM * 1 ML
Alosetron Hydrochloride (GR 68755C) is a potent and highly selective serotonin 5-HT3 receptor antagonist, utilized for irritable bowel syndrome (IBS) research. It blocks 5-HT3-mediated depolarisation of guinea-pig myenteric and submucosal neurons (IC50 ~55 nM), attenuates visceral nociceptive effects, and demonstrates anti-inflammatory effects.
- Potent and highly selective serotonin 5-HT3 receptor antagonist.
- Used for research of irritable bowel syndrome.
- Blocks 5HT3-mediated depolarisation of neurons.
- Attenuates visceral nociceptive effects.
- Demonstrates anti-inflammatory effects.
eMolecules 51285-26-8 | Picolinimidamide hydrochloride | ChemScene | MFCD00052271 | 157.600 | C6H8ClN3 | 95.000 | Cl.NC(=N)c1ccccn1 | 25g | 572163656
Picolinimidamide hydrochloride | ChemScene | 51285-26-8 | MFCD00052271 | 157.600 | C6H8ClN3 | 95.000 | Cl.NC(=N)c1ccccn1 | 25g | 572163656
Medchemexpress LLC 1H-Indene-1,3(2H)-dione, 2,2-dihydroxy- | 485-47-2 | 100.0 % | 100 G
Ninhydrin is a chromogenic analytical probe used for the quantification of amino acids and proteins. It reacts with primary and secondary amines, producing a blue or purple reaction product, diketohydrindylidene-diketohydrindamine. It is utilized in the amino acid analysis of proteins; most amino acids, excluding proline, can be hydrolyzed and react with ninhydrin, after which they are colorimetrically quantified following chromatographic separation.
- Chromogenic analytical probe.
- Reacts with primary and secondary amines.
- Solid appearance, white to light yellow color.
- Quantification of amino acids and proteins.
- Useful in amino acid analysis of proteins.
Medchemexpress LLC Eperisone (hydrochloride) | 56839-43-1 | 99.95% | 1 G
Eperisone hydrochloride is an orally active antispastic agent with a vasodilator effect. It is used for the research of muscle stiffness and pain. This compound is a potent and selective P2X7 receptor antagonist, also exhibiting antagonism for human P2X3. It works by relaxing both skeletal muscles and vascular smooth muscles, demonstrating several beneficial effects.
- Reduces myotonia.
- Improves circulation.
- Suppresses the pain reflex.
- Preferentially suppresses lung fibroblast activity.
- Suppresses bleomycin-dependent pulmonary fibrosis.
- Not toxic to alveolar epithelial cells in vitro.
Medchemexpress LLC Buspirone (hydrochloride) | 33386-08-2 | 99.99 % | 1 G
Buspirone hydrochloride is a 5-HT1A receptor agonist that can be used for anxiety and depression research.
- Has cytotoxic effect in lymphocytes.
- Induces ROS formation, MMP collapse, lipid peroxidation, lysosomal damage, and elevation of glutathione disulfide (GSSG) in lymphocytes.
- Reduces anxiety/depression behaviors in C57BL/6N mice.
- Restores IS-shifted β-diversity in the gut microbiota in C57BL/6N mice.
- Reduced TNF-α expression and NF-κB+/Iba1+ cell population in the hippocampus.
- Reduced myeloperoxidase activity and NF-κB+/CD11c+ cell population in the colon.
- Reduced the IS- or EC-induced gut proteobacteria population.
Medchemexpress LLC Imidapril (hydrochloride) | 89396-94-1 | MFCD00870777 | 99.9% | 100 MG
Imidapril hydrochloride (TA-6366) is an orally active inhibitor of angiotensin-converting enzyme (ACE) and MMP-9. It works by suppressing the conversion of angiotensin I to angiotensin II, which in turn reduces total peripheral resistance and systemic blood pressure. It is used in research for hypertension, type 1 diabetic nephropathy, and chronic heart failure.
- Orally active ACE and MMP-9 inhibitor
- Suppresses conversion of angiotensin I to angiotensin II
- Reduces total peripheral resistance and systemic blood pressure
- Used in research for hypertension
- Used in research for type 1 diabetic nephropathy
- Used in research for chronic heart failure
eMolecules 51285-26-8 | 2-Amidinopyridine Hydrochloride | Accela ChemBio (ASD) | MFCD00052271 | 157.600 | C6H8ClN3 | 95.000 | Cl.NC(=N)c1ccccn1 | 1g | 510407894
2-Amidinopyridine Hydrochloride | Accela ChemBio (ASD) | 51285-26-8 | MFCD00052271 | 157.600 | C6H8ClN3 | 95.000 | Cl.NC(=N)c1ccccn1 | 1g | 510407894
Medchemexpress LLC Lecozotan hydrochloride | 433282-68-9 | 98.7% | 520.02 | 5 MG
Lecozotan hydrochloride (SRA-333) hydrochloride is an orally active and selective antagonist of 5-HT1A with a Ki of 4.5 nM for cloned human 5-HT1A receptor. It enhances the stimulated release of glutamate and acetylcholine in the hippocampus and possesses cognitive-enhancing properties. This product has the potential for mild-to-moderate Alzheimer's disease (AD) research.
- Orally active and selective 5-HT1A antagonist.
- Enhances the release of glutamate and acetylcholine in the hippocampus.
- Possesses cognitive-enhancing properties.
- Potential for mild-to-moderate Alzheimer's disease research.
Medchemexpress LLC Fadrozole hydrochloride | 102676-31-3 | MFCD02313480 | 99.9% | C14H14ClN3 | 10MG
Fadrozole hydrochloride is a potent, selective, nonsteroidal aromatase inhibitor used in biochemical and pharmacological research to inhibit estrogen biosynthesis. It is supplied as the hydrochloride salt with high reported purity and is commonly used in in vitro assays to evaluate aromatase activity and inhibitor potency. The reported IC50 for aromatase inhibition is 6.4 nM.
- Potent aromatase inhibition (IC50 6.4 nM).
- High purity (>99.9%).
- Supplied as a hydrochloride salt for improved handling and solubility.
- Suitable for in vitro biochemical and pharmacological assays.
- Molecular formula C14H14ClN3.
Medchemexpress LLC Ravidasvir hydrochloride | 1303533-81-4 | MFCD32705191 | 99.9% | 835.82 | C42H52Cl2N8O6 | 50MG
Ravidasvir hydrochloride is the hydrochloride salt of ravidasvir, a pan-genotypic hepatitis C virus (HCV) NS5A inhibitor supplied as a high-purity research compound in solid form. It inhibits HCV replication at low nanomolar concentrations and is provided for laboratory research applications.
- High purity (99.9%).
- White to off-white solid physical form.
- Molecular weight 835.82 g/mol.
- Packaged as 50 MG for research use.
- Storage: sealed at 4°C; in solvent: -80°C (up to 6 months) or -20°C (up to 1 month).
- Provides potent pan-genotypic NS5A inhibition with low nanomolar activity.
Medchemexpress LLC Sovesudil hydrochloride | 2984963-50-8 | 99.5% | 443.90 | 25 MG
Sovesudil (PHP-201) hydrochloride is a potent, ATP-competitive, locally acting Rho kinase (ROCK) inhibitor with IC50s of 3.7 and 2.3 nM for ROCK-I and ROCK-II, respectively. It lowers intraocular pressure (IOP) without inducing hyperemia.
- Potent, ATP-competitive, locally acting Rho kinase (ROCK) inhibitor
- IC50s of 3.7 nM for ROCK-I and 2.3 nM for ROCK-II
- Lowers intraocular pressure (IOP) without inducing hyperemia
- Induces altered cellular behavior of human trabecular meshwork (HTM) cells in vitro
- Effectively reduces IOP in ocular normotensive and acute hypertensive rabbits without causing distinct hyperemia in vivo
Medchemexpress LLC Ponatinib hydrochloride | 1114544-31-8 | 99.8% | 569.02 | 25 MG
Ponatinib hydrochloride, also known as AP24534 hydrochloride, is an orally active multi-targeted kinase inhibitor. It inhibits various kinases with IC50s including 0.37 nM for Abl, 1.1 nM for PDGFRα, 1.5 nM for VEGFR2, 2.2 nM for FGFR1, and 5.4 nM for Src.
- Purity of 99.76%
- CAS number: 1114544-31-8
- Molecular weight: 569.02
- Appears as an off-white to light yellow solid
- Soluble in DMSO at 25 mg/mL
- Targets Bcr-Abl, FGFR, PDGFR, VEGFR, Src, and Autophagy pathways
- Store at 4°C, sealed, away from moisture; in solvent, store at -80°C for 6 months or -20°C for 1 month
Medchemexpress LLC AR-C102222 hydrochloride | 1781934-50-6 | 99.8% | 10MM 1ML
AR-C102222 hydrochloride | 1781934-50-6 | 99.8% | 10MM 1ML
Medchemexpress LLC Cl-amidine hydrochloride | 1373232-26-8 | MFCD22201084 | 99.8% | 347.24 | C14H20Cl2N4O2 | 1 ML
Cl-amidine hydrochloride is an orally active peptidylarginine deiminase (PAD) inhibitor used in biochemical, cellular, and in vivo research to block protein citrullination and probe PAD-related pathways.
- Inhibits PAD1, PAD3, and PAD4 with reported IC50 values of 0.8 μM, 6.2 μM, and 5.9 μM.
- Available as a 10 mM solution in DMSO or as solid quantities for formulation flexibility.
- High purity (~99.8%) suitable for biochemical and cellular assays.
- Demonstrated activity in cell apoptosis and neutrophil extracellular trap formation assays.
- Shows efficacy in murine models of colitis and sepsis in published studies.
- Provided supporting documents: data sheet, SDS, COA, HNMR, RP-HPLC, and LCMS.